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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1179604Generated: October 25, 2026

2-Fluorobenzoic acid → 2-Fluoro-N-(3-{1-methyl-2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}phenyl)benzamide

https://huagongshe.com/reaction/1179604

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Fluorobenzoic acidHCID 9935—
Reactant3-{1-Methyl-2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}anilineHCID 57444335—
Product2-Fluoro-N-(3-{1-methyl-2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}phenyl)benzamideHCID 5747835564%

Reaction Steps

The title compound was prepared in 64% yield according to the general procedure for the preparation of amides (Method C) starting from 3-{1-methyl-2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}aniline (D21) and 2-fluorobenzoic acid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07279481B2
Source datasetuspto-grants-2007_10
ORD IDord-fea898ad11d44f0ab460912b8cca7340
Source noteuspto-grants-2007_10