Methanesulfonamide → N-(4-Fluoro-3-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}phenyl)methanesulfonamide

HRID 1179624Notes

Reaction equation

HRID 1179624 reaction equation
Br[C:2]1[CH:3]=[CH:4][C:5]([F:27])=[C:6]([CH2:8][CH2:9][N:10]2[CH2:15][CH2:14][N:13]([C:16]3[CH:25]=[CH:24][CH:23]=[C:22]4[C:17]=3[CH:18]=[CH:19][C:20]([CH3:26])=[N:21]4)[CH2:12][CH2:11]2)[CH:7]=1.[CH3:28][S:29]([NH2:32])(=[O:31])=[O:30]>>[F:27][C:5]1[CH:4]=[CH:3][C:2]([NH:32][S:29]([CH3:28])(=[O:31])=[O:30])=[CH:7][C:6]=1[CH2:8][CH2:9][N:10]1[CH2:15][CH2:14][N:13]([C:16]2[CH:25]=[CH:24][CH:23]=[C:22]3[C:17]=2[CH:18]=[CH:19][C:20]([CH3:26])=[N:21]3)[CH2:12][CH2:11]1

Participants

3

Reactant 2

HCID 72879MethanesulfonamideHCID 574443505-{4-[2-(5-Bromo-2-fluorophenyl)ethyl]-1-piperazinyl}-2-methylquinoline

Product 1

HCID 57444353N-(4-Fluoro-3-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}phenyl)methanesulfonamideYield 69%

Procedure

The title compound was prepared in 69% yield according to the general procedure for the preparation of amides, ureas and carbamates (Method A) starting from 5-{4-[2-(5-bromo-2-fluorophenyl)ethyl]-1-piperazinyl}-2-methylquinoline and methanesulfonamide.

Sources & evidence

ORD record
ord-40ddb0a2f25d4461a22e5d929a9e1c5b
Source dataset
uspto-grants-2007_10
Patent number
US07279481B2

Reaction notes

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