Water → HCID 22047840, compound

HRID 1179697Notes

Reaction equation

HRID 1179697 reaction equation
[OH:1][C:2]1[CH:3]=[CH:4][C:5]([O:8][CH3:9])=[N:6][CH:7]=1.Cl[C:11]1[C:16]([Cl:17])=[CH:15][C:14]([Cl:18])=[CH:13][N:12]=1.[OH-].[K+].O>CS(C)=O>[Cl:17][C:16]1[C:11]([O:1][C:2]2[CH:3]=[CH:4][C:5]([O:8][CH3:9])=[N:6][CH:7]=2)=[N:12][CH:13]=[C:14]([Cl:18])[CH:15]=1

Participants

6

Reactant 4

HCID 962WaterHCID 14797Potassium HydroxideHCID 27666Pyridine, 2,3,5-trichloro-HCID 116223355-Hydroxy-2-methoxypyridine

Product 1

HCID 22047840HCID 22047840, compoundYield 88.2%

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

A solution of 5-hydroxy-2-methoxypyridine (1.25 g, 10.0 mmol), 2,3,5-trichloropyridine (1.82 g, 10.0 mmol) and potassium hydroxide (85% pure, 1.08 g, 10.0 mmol) in dimethyl sulfoxide (25 mL) was heated at 90° C. for 1.5 hours. The solution was poured slowly into water (200 mL). The precipitate was collected by suction, washed thoroughly with water and dried in a vacuum oven at 45° C., yielding the title compound (2.39 g, 88% yield).

Workup

  1. customThe precipitate was collected by suction
  2. washwashed thoroughly with water
  3. customdried in a vacuum oven at 45° C.

Sources & evidence

ORD record
ord-a79c453c5f044f3293eac75233a11d7e
Source dataset
uspto-grants-2007_10
Patent number
US07279470B2

Reaction notes

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