cis-2-(4-Hydroxy-phenyl)hexahydroisoindole-1,3-dione → HCID 69518024, compound

HRID 1179729Notes

Reaction equation

HRID 1179729 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:16](=[O:17])[C@H:15]3[C@H:10]([CH2:11][CH2:12][CH2:13][CH2:14]3)[C:9]2=[O:18])=[CH:4][CH:3]=1.[I-].C[N+]1C=CN([C:26](=[O:35])[N:27]([CH3:34])[C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)C=1>>[O:18]=[C:9]1[C@@H:10]2[C@@H:15]([CH2:14][CH2:13][CH2:12][CH2:11]2)[C:16](=[O:17])[N:8]1[C:5]1[CH:6]=[CH:7][C:2]([O:1][C:26](=[O:35])[N:27]([CH3:34])[C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)=[CH:3][CH:4]=1

Participants

3

Reactant 2

HCID 7035660cis-2-(4-Hydroxy-phenyl)hexahydroisoindole-1,3-dioneHCID 109478841-methyl-3-(methyl-phenyl-carbamoyl)-3H-imidazol-1-ium iodide

Product 1

HCID 69518024HCID 69518024, compoundYield 77.4%

Procedure

The title compound (293 mg, 77% yield, white crystals) was prepared from cis-2-(4-hydroxy-phenyl)hexahydroisoindole-1,3-dione (245 mg, 1.00 mmol) and 1-methyl-3-(methyl-phenyl—carbamoyl)-3H-imidazol-1-ium iodide (343 mg, 1.00 mmol). HPLC-MS m/z=379 (M+1); Rt=4.08 min.

Sources & evidence

ORD record
ord-0af98b1d96ac4e6c9ca94162034f483b
Source dataset
uspto-grants-2007_10
Patent number
US07279470B2

Reaction notes

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