1-methyl-3-(methyl-phenyl-carbamoyl)-3H-imidazol-1-ium iodide → HCID 178485981, compound

HRID 1179732Notes

Reaction equation

HRID 1179732 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([C@H:11]2[CH2:16][CH2:15][C@H:14]([C:17]([CH3:20])([CH3:19])[CH3:18])[CH2:13][CH2:12]2)=[O:10])=[CH:4][CH:3]=1.[I-].C[N+]1C=CN([C:28](=[O:37])[N:29]([CH3:36])[C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)C=1>>[C:17]([C@H:14]1[CH2:15][CH2:16][C@H:11]([C:9]([NH:8][C:5]2[CH:4]=[CH:3][C:2]([O:1][C:28](=[O:37])[N:29]([CH3:36])[C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=3)=[CH:7][CH:6]=2)=[O:10])[CH2:12][CH2:13]1)([CH3:20])([CH3:19])[CH3:18]

Participants

3

Reactant 2

HCID 109478841-methyl-3-(methyl-phenyl-carbamoyl)-3H-imidazol-1-ium iodideHCID 178445655HCID 178445655, compound

Product 1

HCID 178485981HCID 178485981, compoundYield 86.4%

Procedure

The title compound (353 mg, 86% yield, white crystals) was prepared from cis/trans-4-tert-butyl-cyclohexanecarboxylic acid (4-hydroxy-phenyl)-amide (275 mg, 1.00 mmol) and 1-methyl-3-(methyl-phenyl-carbamoyl)-3H-imidazol-1-ium iodide (343 mg, 1.00 mmol). HPLC-MS m/z=409 (M+1); Rt=5.28 and 5.42 min.

Workup

  1. customRt=5.28 and 5.42 min.

Sources & evidence

ORD record
ord-0d49d20d8c6e47b6ac21d1e223d64b0b
Source dataset
uspto-grants-2007_10
Patent number
US07279470B2

Reaction notes

Loading…