Ethyl(phenyl)carbamoyl chloride → Ethyl-phenyl-carbamic Acid 4-(4-trifluoromethyl-phenoxy)-phenyl Ester

HRID 1179746Notes

Reaction equation

HRID 1179746 reaction equation
[F:1][C:2]([F:18])([F:17])[C:3]1[CH:16]=[CH:15][C:6]([O:7][C:8]2[CH:13]=[CH:12][C:11]([OH:14])=[CH:10][CH:9]=2)=[CH:5][CH:4]=1.[CH2:19]([N:21]([C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)[C:22](Cl)=[O:23])[CH3:20]>C(OCC)(=O)C.CCCCCCC>[F:1][C:2]([F:17])([F:18])[C:3]1[CH:16]=[CH:15][C:6]([O:7][C:8]2[CH:9]=[CH:10][C:11]([O:14][C:22](=[O:23])[N:21]([CH2:19][CH3:20])[C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)=[CH:12][CH:13]=2)=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 96376Ethyl(phenyl)carbamoyl chlorideHCID 170230p-(4-(Trifluoromethyl)phenoxy)phenol

Product 1

HCID 10150786Ethyl-phenyl-carbamic Acid 4-(4-trifluoromethyl-phenoxy)-phenyl Ester

Reagents, catalysts & solvents 1

HCID 21899848Ethylacetate heptaneSolvent

Procedure

The title compound was prepared from 4-(4-trifluoromethyl-phenoxy)-phenol and N-ethyl-N-phenylcarbamoyl chloride. The crude product was subjected to flash chromatography (ethyl acetate/heptane, 1:5) (77%, white crystals. HPLC-MS m/z=402.1 (M+1), Rt: 5.6 min.

Sources & evidence

ORD record
ord-75846c97c7e04fb9ad97c7f58b6c9d8d
Source dataset
uspto-grants-2007_10
Patent number
US07279470B2

Reaction notes

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