4-(5-Trifluoromethyl-pyridin-2-yloxy)-phenol → HCID 23635400, compound

HRID 1179749Notes

Reaction equation

HRID 1179749 reaction equation
[F:1][C:2]([F:18])([F:17])[C:3]1[CH:4]=[CH:5][C:6]([O:9][C:10]2[CH:15]=[CH:14][C:13]([OH:16])=[CH:12][CH:11]=2)=[N:7][CH:8]=1.[I-].[C:20]([N:24]([CH3:33])[C:25](N1C=C[N+](C)=C1)=[O:26])([CH3:23])([CH3:22])[CH3:21]>>[F:18][C:2]([F:1])([F:17])[C:3]1[CH:4]=[CH:5][C:6]([O:9][C:10]2[CH:11]=[CH:12][C:13]([O:16][C:25](=[O:26])[N:24]([C:20]([CH3:23])([CH3:22])[CH3:21])[CH3:33])=[CH:14][CH:15]=2)=[N:7][CH:8]=1

Participants

3

Reactant 2

HCID 1552414-(5-Trifluoromethyl-pyridin-2-yloxy)-phenolHCID 86589186HCID 86589186, compound

Product 1

HCID 23635400HCID 23635400, compound

Procedure

The title compound was prepared from 4-(5-trifluoromethyl-pyridin-2-yloxy)-phenol and 3-(tert-Butyl-methyl-carbamoyl)-1-methyl-3H-imidazol-1-ium iodide. The crude product was subjected to preparative HPLC (34%, white crystals). HPLC-MS m/z=369.1 (M+1), Rt: 5.17 min.

Sources & evidence

ORD record
ord-75af82b478bb4bb593903a8c68ec8e90
Source dataset
uspto-grants-2007_10
Patent number
US07279470B2

Reaction notes

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