HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(4-Hydroxyphenoxy)-5-(trifluoromethyl)pyridine-2-carbonitrile → 3,4-Dihydro-2H-quinoline-1-carboxylic acid 4-(2-cyano-5-trifluoromethyl-pyridin-3-yloxy)-phenyl Ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(4-Hydroxyphenoxy)-5-(trifluoromethyl)pyridine-2-carbonitrile | HCID 4313863 | — |
| Reactant | 1-(3,4-Dihydroquinolin-1(2H)-ylcarbonyl)-3-methyl-1H-imidazol-3-ium Iodide | HCID 10959576 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3,4-Dihydro-2H-quinoline-1-carboxylic acid 4-(2-cyano-5-trifluoromethyl-pyridin-3-yloxy)-phenyl Ester | HCID 69519106 | — |
Reaction Steps
The title compound was prepared from 4-(2-cyano-5-trifluoromethyl-pyridin-3-yloxy)-phenol and 3-(3,4-dihydro-2H-quinoline-1-carbonyl)-1-methyl-3H-imidazol-1-ium iodide. The crude product was subjected to flash chromatography (Quad flash 12, dichlormethane) (43%, oil).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07279470B2 |
| Source dataset | uspto-grants-2007_10 |
| ORD ID | ord-48a0f5fb8d4146fdb209162d041a6887 |
| Source note | uspto-grants-2007_10 |