4-Morpholinecarbonyl chloride → HCID 86589204, compound

HRID 1179777Notes

Reaction equation

HRID 1179777 reaction equation
[F:1][C:2]1[CH:21]=[CH:20][C:5]([CH2:6][C:7]2[C:8](=[O:19])[O:9][C:10]3[C:15]([C:16]=2[CH3:17])=[CH:14][CH:13]=[C:12]([OH:18])[CH:11]=3)=[CH:4][CH:3]=1.[N:22]1([C:28](Cl)=[O:29])[CH2:27][CH2:26][O:25][CH2:24][CH2:23]1>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][C:7]2[C:8](=[O:19])[O:9][C:10]3[C:15]([C:16]=2[CH3:17])=[CH:14][CH:13]=[C:12]([O:18][C:28]([N:22]2[CH2:27][CH2:26][O:25][CH2:24][CH2:23]2)=[O:29])[CH:11]=3)=[CH:20][CH:21]=1

Participants

3

Reactant 2

HCID 848104-Morpholinecarbonyl chlorideHCID 5924338HCID 5924338, compound

Product 1

HCID 86589204HCID 86589204, compound

Procedure

The title compound was prepared from 3-(4-fluorobenzyl)-7-hydroxy-4-methyl-2H-chromen-2-one and morpholine-4-carbonyl chloride. The crude product was recrystallized (ethanol) (78%, crystals). HPLC-MS m/z=398.0 (M+1), Rt: 4.3 min.

Workup

  1. customThe crude product was recrystallized (ethanol) (78%, crystals)

Sources & evidence

ORD record
ord-61c8d76a697947e2aa578bdd644afb12
Source dataset
uspto-grants-2007_10
Patent number
US07279470B2

Reaction notes

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