7-Hydroxy-3-(4-methoxyphenyl)-4-methyl-2H-1-benzopyran-2-one → 3-(4-methoxyphenyl)-4-methyl-2-oxo-2H-chromen-7-yl morpholine-4-carboxylate

HRID 1179780Notes

Reaction equation

HRID 1179780 reaction equation
[OH:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([CH3:21])=[C:7]([C:13]3[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[CH:15][CH:14]=3)[C:8](=[O:12])[O:9]2)=[CH:4][CH:3]=1.[I-].C[N+]1C=CN([C:29]([N:31]2[CH2:36][CH2:35][O:34][CH2:33][CH2:32]2)=[O:30])C=1>>[CH3:20][O:19][C:16]1[CH:17]=[CH:18][C:13]([C:7]2[C:8](=[O:12])[O:9][C:10]3[C:5]([C:6]=2[CH3:21])=[CH:4][CH:3]=[C:2]([O:1][C:29]([N:31]2[CH2:36][CH2:35][O:34][CH2:33][CH2:32]2)=[O:30])[CH:11]=3)=[CH:14][CH:15]=1

Participants

3

Reactant 2

HCID 53576277-Hydroxy-3-(4-methoxyphenyl)-4-methyl-2H-1-benzopyran-2-oneHCID 11220989223762-21-8

Product 1

HCID 71982613-(4-methoxyphenyl)-4-methyl-2-oxo-2H-chromen-7-yl morpholine-4-carboxylateYield 61%

Procedure

The title compound (120 mg, 61% yield, crystals) was prepared from 7-hydroxy-3-(4-methoxy-phenyl)-4-methyl-chromen-2-one (141 mg, 0.50 mmol) and 1-methyl-3-(morpholine-4-carbonyl)-3H-imidazol-1-ium iodide (165 mg, 0.51 mmol).

Sources & evidence

ORD record
ord-d8f8dbfc68db4c079226761fe87ebaef
Source dataset
uspto-grants-2007_10
Patent number
US07279470B2

Reaction notes

Loading…