4-(5-Trifluoromethyl-pyridin-2-yloxy)-phenol → HCID 23635513, compound

HRID 1179783Notes

Reaction equation

HRID 1179783 reaction equation
[F:1][C:2]([F:18])([F:17])[C:3]1[CH:4]=[CH:5][C:6]([O:9][C:10]2[CH:15]=[CH:14][C:13]([OH:16])=[CH:12][CH:11]=2)=[N:7][CH:8]=1.[I-].[CH3:20][CH:21]1[O:26][CH:25]([CH3:27])[CH2:24][N:23]([C:28](N2C=C[N+](C)=C2)=[O:29])[CH2:22]1>>[F:18][C:2]([F:1])([F:17])[C:3]1[CH:4]=[CH:5][C:6]([O:9][C:10]2[CH:11]=[CH:12][C:13]([O:16][C:28]([N:23]3[CH2:24][CH:25]([CH3:27])[O:26][CH:21]([CH3:20])[CH2:22]3)=[O:29])=[CH:14][CH:15]=2)=[N:7][CH:8]=1

Participants

3

Reactant 2

HCID 1552414-(5-Trifluoromethyl-pyridin-2-yloxy)-phenolHCID 21925205HCID 21925205, compound

Product 1

HCID 23635513HCID 23635513, compound

Procedure

The title compound was prepared from 4-(5-trifluoromethyl-pyridin-2-yloxy)-phenol and 3-(2,6-dimethyl-morpholine-4-carbonyl)-1-methyl-3H-imidazol-1-ium iodide. The crude product was purified by preparative HPLC (39%, colorless oil). HPLC-MS m/z=397.1 (M+1), Rt: 4.64 min.

Workup

  1. customThe crude product was purified by preparative HPLC (39%, colorless oil)

Sources & evidence

ORD record
ord-7126cac9717b4928a99a32d6aadd1321
Source dataset
uspto-grants-2007_10
Patent number
US07279470B2

Reaction notes

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