Carbamic chloride, N-methyl-N-phenyl- → Methyl-phenyl-carbamic Acid pyrazol-1-yl Ester

HRID 1179784Notes

Reaction equation

HRID 1179784 reaction equation
[OH:1][N:2]1[CH:6]=[CH:5][CH:4]=[N:3]1.[CH3:7][N:8]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[C:9](Cl)=[O:10]>CCOC(C)=O.CCCCCCC>[N:2]1([O:1][C:9](=[O:10])[N:8]([CH3:7])[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:6]=[CH:5][CH:4]=[N:3]1

Participants

4

Reactant 2

HCID 77969Carbamic chloride, N-methyl-N-phenyl-HCID 30167331-hydroxy-1H-pyrazole

Product 1

HCID 10149109Methyl-phenyl-carbamic Acid pyrazol-1-yl Ester

Reagents, catalysts & solvents 1

HCID 21899848Ethylacetate heptaneSolvent

Procedure

The title compound was prepared from 1-hydroxypyrazole and N-methyl-N-phenylcarbamoyl chloride. The crude product was subjected to flash chromatography (Quad flash 25, EtOAc-heptane) (79%, oil which slowly crystallizes). HPLC-MS m/z=218.1 (M+1), Rt: 2.82 min. Mp 63-67° C.

Workup

  1. customslowly crystallizes)

Sources & evidence

ORD record
ord-36964661979744cbaf299bc72ba2123f
Source dataset
uspto-grants-2007_10
Patent number
US07279470B2

Reaction notes

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