5,6,7,8-Tetrahydro-1-naphthol → Methyl-phenyl-carbamic Acid 5,6,7,8-tetrahydro-naphthalen-1-yl Ester

HRID 1179818Notes

Reaction equation

HRID 1179818 reaction equation
[C:1]1([OH:11])[C:10]2[CH2:9][CH2:8][CH2:7][CH2:6][C:5]=2[CH:4]=[CH:3][CH:2]=1.[CH3:12][N:13]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[C:14](Cl)=[O:15]>>[C:1]1([O:11][C:14](=[O:15])[N:13]([CH3:12])[C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[C:10]2[CH2:9][CH2:8][CH2:7][CH2:6][C:5]=2[CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 682585,6,7,8-Tetrahydro-1-naphtholHCID 77969Carbamic chloride, N-methyl-N-phenyl-

Product 1

HCID 69518203Methyl-phenyl-carbamic Acid 5,6,7,8-tetrahydro-naphthalen-1-yl Ester

Procedure

The title product was prepared from 5,6,7,8-tetrahydro-1-naphthol and N-methyl-N-phenylcarbamoyl chloride. The crude product was subjected to preparative HPLC (42%, colorless oil). HPLC-MS: m/z=282.1 (M+1); Rt: 4.77 min.

Sources & evidence

ORD record
ord-244aa600e3954e6d893a93d431f65c62
Source dataset
uspto-grants-2007_10
Patent number
US07279470B2

Reaction notes

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