4-Piperidinemethanol → HCID 69519363, compound

HRID 1179821Notes

Reaction equation

HRID 1179821 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:8][C:9]2[CH:14]=[CH:13][C:12]([OH:15])=[CH:11][CH:10]=2)=[N:6][CH:7]=1.[OH:16][CH2:17][CH:18]1[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]1.[C:24](OCC)(=[O:26])C.CCCCCCC>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:8][C:9]2[CH:14]=[CH:13][C:12]([O:15][C:24]([N:21]3[CH2:22][CH2:23][CH:18]([CH2:17][OH:16])[CH2:19][CH2:20]3)=[O:26])=[CH:11][CH:10]=2)=[N:6][CH:7]=1

Participants

4

Reactant 3

HCID 4207714-PiperidinemethanolHCID 21655016HCID 21655016, compoundHCID 21899848Ethylacetate heptane

Product 1

HCID 69519363HCID 69519363, compound

Procedure

The title product was prepared from 4-(5-chloro-pyridin-2-yloxy)-phenol and 4-hydroxymethyl-piperidine. The crude product was subjected to column chromatography (ethyl acetate/heptane, 1:1) (75%, colorless oil). HPLC-MS: m/z=363.1 (M+1); Rt: 3.58 min.

Sources & evidence

ORD record
ord-8b06c3cff6fb489aa4256294a5a1a388
Source dataset
uspto-grants-2007_10
Patent number
US07279470B2

Reaction notes

Loading…