4-Chlorobenzylpiperazine → 4-(4-Chlorobenzyl)piperazine-1-carboxylic Acid 4-(4-trifluoromethylphenoxy)phenyl Ester

Participants

Reaction Steps

The hydrochloride of the title compound was prepared from 4-(4-trifluoromethylphenoxy)phenyl chloroformate and 1-(4-chlorobenzyl)piperazine, yield 86% White crystals, m.p. 232-234° C.; 1H NMR (DMSO-d6): δ11.92 (br s, 1H), 3 AB-systems: 7.83-7.62 (t-like, 4H) and 7.62-7.48 (d-like, 2H), and 7.32-7.07 (m, 6H); 4.51-3.95 (br s at 4.37 ppm overlapping with br signal at 4.2 ppm, 4H), 3.95-2.95 (br m, 9H: 6H+water); IR (KBr): ν 1717 (C═O) cm−1.

Provenance & Evidence