Carbamic chloride, N-methyl-N-phenyl- → HCID 69519016, compound

HRID 1179908Notes

Reaction equation

HRID 1179908 reaction equation
[OH:1][N:2]1[C:6]([C:7]2[CH:12]=[CH:11][C:10]([O:13][CH3:14])=[CH:9][CH:8]=2)=[C:5]([C:15]2[CH:20]=[CH:19][C:18]([F:21])=[CH:17][CH:16]=2)[C:4]([C:22]2[CH:27]=[CH:26][C:25]([CH3:28])=[CH:24][CH:23]=2)=[N:3]1.[CH3:29][N:30]([C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1)[C:31](Cl)=[O:32]>>[F:21][C:18]1[CH:19]=[CH:20][C:15]([C:5]2[C:4]([C:22]3[CH:23]=[CH:24][C:25]([CH3:28])=[CH:26][CH:27]=3)=[N:3][N:2]([O:1][C:31](=[O:32])[N:30]([CH3:29])[C:34]3[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=3)[C:6]=2[C:7]2[CH:12]=[CH:11][C:10]([O:13][CH3:14])=[CH:9][CH:8]=2)=[CH:16][CH:17]=1

Participants

3

Reactant 2

HCID 77969Carbamic chloride, N-methyl-N-phenyl-HCID 11057833HCID 11057833, compound

Product 1

HCID 69519016HCID 69519016, compound

Procedure

The title compound was prepared from 1-hydroxy-4-(4-fluorophenyl)-5-(4-methoxyphenyl)-3-(4-methylphenyl)pyrazole and N-methyl-N-phenylcarbamoyl chloride applying the general procedure 8. The crude product was purified by flash chromatography (Quad flash 12, EtOAc-heptane) (11%, crystals).

Workup

  1. customThe crude product was purified by flash chromatography (Quad flash 12, EtOAc-heptane) (11%, crystals)

Sources & evidence

ORD record
ord-5d0862be70d340eca6914b0a7a0770bb
Source dataset
uspto-grants-2007_10
Patent number
US07279470B2

Reaction notes

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