Dabco → Carbamic acid, methylphenyl-, 5-[[(2,2-dimethylpropyl)amino]carbonyl]-2-pyridinyl ester

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Reaction Steps

A solution of N-(2,2-dimethyl-propyl)-6-hydroxy-nicotinamide (0.50 g, 2.40 mmol), N-methyl-N-phenylcarbamoyl chloride (0.41 g, 2.40 mmol) and 1,4-diazabicyclo[2,2,2]octane (0.27 g, 2.40 mmol) in tetrahydrofuran (15 mL) was stirred at room temperature for 3 hours. The solvent was evaporated in vacuo and the residue was purified by flash column chromatography (first column: SiO2, dichloromethane:ethyl acetate 95:5, second column: SiO2, ethyl acetate), yielding the title compound (0.43 g, 52% yield).

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