HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Bromide → 4-Cyclohexylmethyl-piperazine-1-carboxylic Acid 4-(3-chloro-5-trifluoromethyl-pyridin-2-yloxy)-phenyl Ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Bromide | HCID 253877 | — |
| Reactant | 1-(Cyclohexylmethyl)piperazine | HCID 2735885 | — |
| Reactant | 4-(3-Chloro-5-trifluoromethylpyridin-2-yloxy)-phenyl chloroformate | HCID 22047691 | — |
| Product | 4-Cyclohexylmethyl-piperazine-1-carboxylic Acid 4-(3-chloro-5-trifluoromethyl-pyridin-2-yloxy)-phenyl Ester | HCID 69518167 | — |
Reaction Steps
The hydrochloride of the title compound was prepared from 4-(3-chloro-5-trifluoromethyl-pyridin-2-yloxy)-phenyl chloroformate and 1-cyclohexylmethyl-piperazine, yield 76%. White crystals, m.p. 265-266° C.; IR (KBr): ν 1732 (C═O) cm−1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07279470B2 |
| Source dataset | uspto-grants-2007_10 |
| ORD ID | ord-5e2a401ef55446f6994f8f54f83438da |
| Source note | uspto-grants-2007_10 |