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Potassium Bromide → 4-(Tetrahydrofuran-2-ylmethyl)-piperazine-1-carboxylic acid 4-(3-chloro-5-trifluoromethylpyridin-2-yloxy)-phenyl Ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Bromide | HCID 253877 | — |
| 反応物 | 1-(Tetrahydro-2-furylmethyl)piperazine | HCID 2737265 | — |
| 反応物 | 4-(3-Chloro-5-trifluoromethylpyridin-2-yloxy)-phenyl chloroformate | HCID 22047691 | — |
| 生成物 | 4-(Tetrahydrofuran-2-ylmethyl)-piperazine-1-carboxylic acid 4-(3-chloro-5-trifluoromethylpyridin-2-yloxy)-phenyl Ester | HCID 69518673 | — |
反応手順
The hydrochloride of the title compound was prepared from 4-(3-chloro-5-trifluoromethyl-pyridin-2-yloxy)-phenyl chloroformate and 1-(tetrahydrofuran-2-ylmethyl)-piperazine, yield 23%. White crystals, m.p. 98-100° C.; IR (KBr): ν 1731 (C═O) cm−1.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07279470B2 |
| 出典データセット | uspto-grants-2007_10 |
| ORD ID | ord-aade07bb87eb406d837552e87f8d4d03 |
| 出典メモ | uspto-grants-2007_10 |