HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Bromide → HCID 69518987, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Bromide | HCID 253877 | — |
| Reactant | 1-[(5-Chloro-2-thienyl)methyl]piperazine | HCID 2455012 | — |
| Reactant | 4-(5-Trifluoromethylpyridin-2-yloxy)-phenyl chloroformate | HCID 22047762 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 69518987 | HCID 69518987 | — |
Reaction Steps
The hydrochloride of the title compound was prepared from 4-(5-trifluoromethyl-pyridin-2-yloxy)-phenyl chloroformate and 1-(5-chloro-thiophen-2-ylmethyl)-piperazine, yield 48%. White crystals, m.p. 225-226° C. (from EtOH); 1H NMR (DMSO-d6): δ 12.00 (br, 1H), 8.60-8.55 (1H), 8.27-8.21 (dd-like, 1H), 7.33-7.20 (m, 6H), 7.20-7.15 (d, 1H), 4.55 (br s, 2H), 4.40-4.00 (br, 2H), 3.74-3.27 (br, 4H+H2O); 3.27-2.97 (br, 2H); IR (KBr): ν 1723 (C═O) cm1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07279470B2 |
| Source dataset | uspto-grants-2007_10 |
| ORD ID | ord-d2f36d9a5b89441b9ebb798b870fd85d |
| Source note | uspto-grants-2007_10 |