4-(Aminomethyl)piperidine → HCID 69519296, compound

HRID 1179968Notes

Reaction equation

HRID 1179968 reaction equation
Cl[C:2]([O:4][C:5]1[CH:10]=[CH:9][C:8]([O:11][C:12]2[CH:17]=[CH:16][C:15]([C:18]([F:21])([F:20])[F:19])=[CH:14][N:13]=2)=[CH:7][CH:6]=1)=[O:3].[NH2:22][CH2:23][CH:24]1[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]1>>[F:19][C:18]([F:21])([F:20])[C:15]1[CH:16]=[CH:17][C:12]([O:11][C:8]2[CH:9]=[CH:10][C:5]([O:4][C:2]([N:27]3[CH2:28][CH2:29][CH:24]([CH2:23][NH2:22])[CH2:25][CH2:26]3)=[O:3])=[CH:6][CH:7]=2)=[N:13][CH:14]=1

Participants

3

Reactant 2

HCID 235274-(Aminomethyl)piperidineHCID 220477624-(5-Trifluoromethylpyridin-2-yloxy)-phenyl chloroformate

Product 1

HCID 69519296HCID 69519296, compound

Procedure

The title compound was prepared from 4-(5-trifluoromethyl-pyridin-2-yloxy)-phenyl chloroformate and 4-aminomethylpiperidine. The crude product was purified by preparative HPLC (Method C) (32%, off-white crystals). HPLC-MS m/z=396.1 (M+1), Rt: 2.65 min. purity: 86%.

Workup

  1. customThe crude product was purified by preparative HPLC (Method C) (32%, off-white crystals)

Sources & evidence

ORD record
ord-5045feb7318c4270bd82b19e04ab1205
Source dataset
uspto-grants-2007_10
Patent number
US07279470B2

Reaction notes

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