反应详情

The crude product was prepared from 4-(5-trifluoromethyl-pyridin-2-yloxy)-phenyl chloroformate and and 2-methoxy-6-methylaminopyridine. The reaction mixture was evaporated to dryness, dissolved in dichloromethane (100 ml) and extracted with a aqueous phosphate buffer, pH 7. The aqueous phase was extracted with dichloromethane (100 ml×2) and the combined organic phases were dried and evaporated to dryness. The product was subjected to flash chromatography, ethyl acetate/heptane (1:7) to give the titlew product (86%, white crystals). HPLC-MS m/z=420.4 (M+1), Rt: 5.23 min.

1. customThe reaction mixture was evaporated to dryness
2. dissolutiondissolved in dichloromethane (100 ml)
3. extractionextracted with a aqueous phosphate buffer, pH 7
4. extractionThe aqueous phase was extracted with dichloromethane (100 ml×2)
5. customthe combined organic phases were dried
6. customevaporated to dryness
7. customto give the titlew product (86%, white crystals)