Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1179978Generated: October 25, 2026

Diisopropylamine → 4-Benzimidazol-1-yl-piperidine-1-carboxylic acid 4-(5-trifluoromethyl-pyridin-2-yloxy)-phenyl Ester

https://huagongshe.com/reaction/1179978

Reaction equation

Participants

RoleNameHCIDCharge
ReactantDiisopropylamineHCID 7912—
Reactant1-(4-Piperidinyl)-1H-benzimidazoleHCID 3019262—
Reactant4-(5-Trifluoromethylpyridin-2-yloxy)-phenyl chloroformateHCID 22047762—
Product4-Benzimidazol-1-yl-piperidine-1-carboxylic acid 4-(5-trifluoromethyl-pyridin-2-yloxy)-phenyl EsterHCID 69517889—

Reaction Steps

The crude product was prepared from 4-(5-trifluoromethyl-pyridin-2-yloxy)-phenyl chloroformate and 1-piperidine-4-yl-1H-benzimidazole, 5 equivalent of diisopropylamine was added, preparative HPLC (method C) (23%, colourless crystals). HPLC-MS m/z=483.3 (M+1), Rt: 3.14 min.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07279470B2
Source datasetuspto-grants-2007_10
ORD IDord-dcc0e3de853d46eca584c1b60bb21762
Source noteuspto-grants-2007_10