4-(5-Trifluoromethylpyridin-2-yloxy)-phenyl chloroformate → HCID 69519048, compound

HRID 1179981Notes

Reaction equation

HRID 1179981 reaction equation
Cl[C:2]([O:4][C:5]1[CH:10]=[CH:9][C:8]([O:11][C:12]2[CH:17]=[CH:16][C:15]([C:18]([F:21])([F:20])[F:19])=[CH:14][N:13]=2)=[CH:7][CH:6]=1)=[O:3].Cl.[CH3:23][N:24]([CH:32]1[CH2:37][CH2:36][NH:35][CH2:34][CH2:33]1)[CH2:25][C:26]1[CH:27]=[N:28][CH:29]=[CH:30][CH:31]=1>>[F:19][C:18]([F:21])([F:20])[C:15]1[CH:16]=[CH:17][C:12]([O:11][C:8]2[CH:9]=[CH:10][C:5]([O:4][C:2]([N:35]3[CH2:36][CH2:37][CH:32]([N:24]([CH3:23])[CH2:25][C:26]4[CH:27]=[N:28][CH:29]=[CH:30][CH:31]=4)[CH2:33][CH2:34]3)=[O:3])=[CH:6][CH:7]=2)=[N:13][CH:14]=1

Participants

3

Reactant 2

HCID 220477624-(5-Trifluoromethylpyridin-2-yloxy)-phenyl chloroformateHCID 71641672HCID 71641672, compound

Product 1

HCID 69519048HCID 69519048, compound

Procedure

The title compound was prepared from 4-(5-trifluoromethyl-pyridin-2-yloxy)-phenyl chloroformate and methyl-piperidin-4-yl-pyridin-3-ylmethyl-amine, hydrochloride, preparative HPLC (Method C) (31%, orange oil). HPLC-MS m/z=487.1 (M+1), Rt: 2.64 min.

Sources & evidence

ORD record
ord-e66adc59d0a44a19988373ba20ae33eb
Source dataset
uspto-grants-2007_10
Patent number
US07279470B2

Reaction notes

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