Diisopropylamine → HCID 69520478, compound

HRID 1179985Notes

Reaction equation

HRID 1179985 reaction equation
Cl[C:2]([O:4][C:5]1[CH:10]=[CH:9][C:8]([O:11][C:12]2[CH:17]=[CH:16][C:15]([C:18]([F:21])([F:20])[F:19])=[CH:14][N:13]=2)=[CH:7][CH:6]=1)=[O:3].Cl.[CH:23]1([N:29]([CH3:37])[CH2:30][CH:31]2[CH2:36][CH2:35][NH:34][CH2:33][CH2:32]2)[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]1.C(NC(C)C)(C)C>>[F:19][C:18]([F:21])([F:20])[C:15]1[CH:16]=[CH:17][C:12]([O:11][C:8]2[CH:9]=[CH:10][C:5]([O:4][C:2]([N:34]3[CH2:35][CH2:36][CH:31]([CH2:30][N:29]([CH:23]4[CH2:24][CH2:25][CH2:26][CH2:27][CH2:28]4)[CH3:37])[CH2:32][CH2:33]3)=[O:3])=[CH:6][CH:7]=2)=[N:13][CH:14]=1

Participants

4

Reactant 3

HCID 7912DiisopropylamineHCID 220477624-(5-Trifluoromethylpyridin-2-yloxy)-phenyl chloroformateHCID 119929256HCID 119929256, compound

Product 1

HCID 69520478HCID 69520478, compound

Procedure

The title compound was prepared from 4-(5-trifluoromethyl-pyridin-2-yloxy)-phenyl chloroformate and cyclohexyl-methyl-piperidine-4-ylmethyl-amine, hydrochloride, 5 equivalent of diisopropylamine was added, preparative HPLC (Method C) (43%, white crystals). HPLC-MS m/z=492.3 (M+1), Rt: 3.22 min.

Workup

  1. additionwas added

Sources & evidence

ORD record
ord-6109cdf00af74e7d9c85cfe9144131fb
Source dataset
uspto-grants-2007_10
Patent number
US07279470B2

Reaction notes

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