Diisopropylamine → HCID 69517876, compound

HRID 1179986Notes

Reaction equation

HRID 1179986 reaction equation
Cl[C:2]([O:4][C:5]1[CH:10]=[CH:9][C:8]([O:11][C:12]2[CH:17]=[CH:16][C:15]([C:18]([F:21])([F:20])[F:19])=[CH:14][N:13]=2)=[CH:7][CH:6]=1)=[O:3].Cl.[CH2:23]([N:25]([CH2:33][CH:34]1[CH2:39][CH2:38][NH:37][CH2:36][CH2:35]1)[CH2:26][C:27]1[CH:32]=[CH:31][N:30]=[CH:29][CH:28]=1)[CH3:24].C(NC(C)C)(C)C>>[F:19][C:18]([F:21])([F:20])[C:15]1[CH:16]=[CH:17][C:12]([O:11][C:8]2[CH:9]=[CH:10][C:5]([O:4][C:2]([N:37]3[CH2:36][CH2:35][CH:34]([CH2:33][N:25]([CH2:23][CH3:24])[CH2:26][C:27]4[CH:32]=[CH:31][N:30]=[CH:29][CH:28]=4)[CH2:39][CH2:38]3)=[O:3])=[CH:6][CH:7]=2)=[N:13][CH:14]=1

Participants

4

Reactant 3

HCID 7912DiisopropylamineHCID 220477624-(5-Trifluoromethylpyridin-2-yloxy)-phenyl chloroformateHCID 131725816HCID 131725816, compound

Product 1

HCID 69517876HCID 69517876, compound

Procedure

The title compound was prepared from 4-(5-trifluoromethyl-pyridin-2-yloxy)-phenyl chloroformate and ethyl-piperidin-4-ylmethyl-pyridin-4-ylmethyl-amine, hydrochloride, 5 equivalent of diisopropylamine was added, preparative HPLC (Method C) (25%, off-white crystals). HPLC-MS m/z=515.2 (M+1), Rt: 2.77 min.

Workup

  1. additionwas added

Sources & evidence

ORD record
ord-4cb642cb928640cbaa4cb7efdaf56808
Source dataset
uspto-grants-2007_10
Patent number
US07279470B2

Reaction notes

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