Diisopropylamine → HCID 69520000, compound

HRID 1179988Notes

Reaction equation

HRID 1179988 reaction equation
Cl[C:2]([O:4][C:5]1[CH:10]=[CH:9][C:8]([O:11][C:12]2[CH:17]=[CH:16][C:15]([C:18]([F:21])([F:20])[F:19])=[CH:14][N:13]=2)=[CH:7][CH:6]=1)=[O:3].Cl.[CH3:23][N:24]([CH2:32][CH:33]1[CH2:38][CH2:37][NH:36][CH2:35][CH2:34]1)[CH2:25][C:26]1[CH:31]=[CH:30]N=C[CH:27]=1.[CH:39]([NH:42]C(C)C)(C)C>>[F:19][C:18]([F:21])([F:20])[C:15]1[CH:16]=[CH:17][C:12]([O:11][C:8]2[CH:9]=[CH:10][C:5]([O:4][C:2]([N:36]3[CH2:35][CH2:34][CH:33]([CH2:32][N:24]([CH3:23])[CH2:25][C:26]4[CH:27]=[N:42][CH:39]=[CH:30][CH:31]=4)[CH2:38][CH2:37]3)=[O:3])=[CH:6][CH:7]=2)=[N:13][CH:14]=1

Participants

4

Reactant 3

HCID 7912DiisopropylamineHCID 220477624-(5-Trifluoromethylpyridin-2-yloxy)-phenyl chloroformateHCID 71642483HCID 71642483, compound

Product 1

HCID 69520000HCID 69520000, compound

Procedure

The title compound was prepared from 4-(5-trifluoromethyl-pyridin-2-yloxy)-phenyl chloroformate and methyl-piperidine-4-ylmethyl-pyridine-4-ylmethyl-amine, hydrochloride, 5 equivalent of diisopropylamine was added, preparative HPLC (Method C) (36%, colourless crystals). HPLC-MS m/z=501.1 (M+1), Rt: 2.74 min.

Workup

  1. additionwas added

Sources & evidence

ORD record
ord-36cd2bc3a65b4a7a9e7a831d171b496e
Source dataset
uspto-grants-2007_10
Patent number
US07279470B2

Reaction notes

Loading…