Diisopropylamine → HCID 69518481, compound

HRID 1179991Notes

Reaction equation

HRID 1179991 reaction equation
[CH3:1][N:2]([CH:11]1[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]1)[CH2:3][CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][N:6]=1.Cl[C:18]([O:20][C:21]1[CH:26]=[CH:25][C:24]([O:27][C:28]2[CH:33]=[CH:32][C:31]([C:34]([F:37])([F:36])[F:35])=[CH:30][N:29]=2)=[CH:23][CH:22]=1)=[O:19].C(NC(C)C)(C)C>>[F:36][C:34]([F:35])([F:37])[C:31]1[CH:32]=[CH:33][C:28]([O:27][C:24]2[CH:25]=[CH:26][C:21]([O:20][C:18]([N:14]3[CH2:15][CH2:16][CH:11]([N:2]([CH3:1])[CH2:3][CH2:4][C:5]4[CH:10]=[CH:9][CH:8]=[CH:7][N:6]=4)[CH2:12][CH2:13]3)=[O:19])=[CH:22][CH:23]=2)=[N:29][CH:30]=1

Participants

4

Reactant 3

HCID 7912DiisopropylamineHCID 220477624-(5-Trifluoromethylpyridin-2-yloxy)-phenyl chloroformateHCID 22047807HCID 22047807, compound

Product 1

HCID 69518481HCID 69518481, compound

Procedure

The title product was prepared from methyl-piperidin-4-yl-(2-pyridin-2-yl-ethyl)-amine and 4-(5-trifluoromethyl-pyridin-2-yloxy)-phenyl chloroformate, 5 equivalent of diisopropylamine was added, preparative HPLC (method C) (48%, colourless oil). HPLC-MS m/z=501.1 (M+1), Rt: 2.77 min.

Workup

  1. additionwas added

Sources & evidence

ORD record
ord-cab1e4de28dd496f8e25e470264b673c
Source dataset
uspto-grants-2007_10
Patent number
US07279470B2

Reaction notes

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