Benzamide, 5-chloro-2-(methylamino)- → HCID 69519445, compound

HRID 1179995Notes

Reaction equation

HRID 1179995 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([NH:11][CH3:12])=[C:6]([CH:10]=1)[C:7]([NH2:9])=[O:8].Cl[C:14]([O:16][C:17]1[CH:22]=[CH:21][C:20]([O:23][C:24]2[CH:29]=[CH:28][C:27]([C:30]([F:33])([F:32])[F:31])=[CH:26][N:25]=2)=[CH:19][CH:18]=1)=[O:15]>>[F:31][C:30]([F:33])([F:32])[C:27]1[CH:28]=[CH:29][C:24]([O:23][C:20]2[CH:21]=[CH:22][C:17]([O:16][C:14](=[O:15])[N:11]([C:5]3[CH:4]=[CH:3][C:2]([Cl:1])=[CH:10][C:6]=3[C:7](=[O:8])[NH2:9])[CH3:12])=[CH:18][CH:19]=2)=[N:25][CH:26]=1

Participants

3

Reactant 2

HCID 97387Benzamide, 5-chloro-2-(methylamino)-HCID 220477624-(5-Trifluoromethylpyridin-2-yloxy)-phenyl chloroformate

Product 1

HCID 69519445HCID 69519445, compound

Procedure

The title product was prepared from 5-chloro-2-(methylamino)-benzamide and 4-(5-trifluoromethyl-pyridin-2-yloxy)-phenyl chloroformate, preparative HPLC (method C) (31%, light yellow oil). HPLC-MS m/z=466.1 (M+1), Rt: 3.99 min.

Sources & evidence

ORD record
ord-42e0e56b81f3424ebb93bb3e1014eb4a
Source dataset
uspto-grants-2007_10
Patent number
US07279470B2

Reaction notes

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