2-(Methylamino)benzamide → (2-Carbamoyl-phenyl)-methyl-carbamic Acid 4-(5-trifluoromethyl-pyridin-2-yloxy)-phenyl Ester

HRID 1179996Notes

Reaction equation

HRID 1179996 reaction equation
[CH3:1][NH:2][C:3]1[CH:11]=[CH:10][CH:9]=[CH:8][C:4]=1[C:5]([NH2:7])=[O:6].Cl[C:13]([O:15][C:16]1[CH:21]=[CH:20][C:19]([O:22][C:23]2[CH:28]=[CH:27][C:26]([C:29]([F:32])([F:31])[F:30])=[CH:25][N:24]=2)=[CH:18][CH:17]=1)=[O:14]>>[F:30][C:29]([F:32])([F:31])[C:26]1[CH:27]=[CH:28][C:23]([O:22][C:19]2[CH:20]=[CH:21][C:16]([O:15][C:13](=[O:14])[N:2]([C:3]3[CH:11]=[CH:10][CH:9]=[CH:8][C:4]=3[C:5](=[O:6])[NH2:7])[CH3:1])=[CH:17][CH:18]=2)=[N:24][CH:25]=1

Participants

3

Reactant 2

HCID 1012222-(Methylamino)benzamideHCID 220477624-(5-Trifluoromethylpyridin-2-yloxy)-phenyl chloroformate

Product 1

HCID 69517964(2-Carbamoyl-phenyl)-methyl-carbamic Acid 4-(5-trifluoromethyl-pyridin-2-yloxy)-phenyl Ester

Procedure

The title product was prepared from 2-(methylamino)benzamide and 4-(5-trifluoromethyl-pyridin-2-yloxy)-phenyl chloroformate, preparative HPLC (method C) (57%, light yellow oil). HPLC-MS m/z=454.2 (M+Na), Rt: 3.66 min.

Sources & evidence

ORD record
ord-e0b5d03f66844756927aceb61b27934d
Source dataset
uspto-grants-2007_10
Patent number
US07279470B2

Reaction notes

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