Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-[(Pyridin-3-yl)methyl]piperazine → 4-Pyridin-3-ylmethyl-piperazine-1-carboxylic Acid 4-(3,3-dimethyl-butylcarbamoyl)-phenyl Ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-[(Pyridin-3-yl)methyl]piperazine | HCID 156975 | — |
| 반응물 | 4-(3,3-Dimethyl-butylcarbamoyl)-phenyl chloroformate | HCID 22047873 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 4-Pyridin-3-ylmethyl-piperazine-1-carboxylic Acid 4-(3,3-dimethyl-butylcarbamoyl)-phenyl Ester | HCID 69519117 | — |
반응 단계
The title product was prepared from 1-pyridin-3-ylmethyl-piperazine was dissolved in dichloromethane (5 ml). 4-(3,3-Dimethyl-butylcarbamoyl)-phenyl chloroformate (0.35 mmol) was added at room temperature. The reaction mixture was stirred for 16 h and evaporated to dryness and subjected to preparative HPLC (method C) (88%, light yellow oil). HPLC-MS m/z=425.4 (M+1), Rt: 2.33 min.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07279470B2 |
| 출처 데이터셋 | uspto-grants-2007_10 |
| ORD ID | ord-578e194b6ae645a58fb684229c864082 |
| 출처 메모 | uspto-grants-2007_10 |