tert-Butyl piperazine-1-carboxylate → HCID 69519830, compound

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Reaction Steps

The title compound was prepared from 4-(5-trifluoromethyl-pyridin-2-yloxy)-phenyl chloroformate and 1-tert-butoxycarbonyl-piperazin, yield 59% (recrystallized from EtOAc—heptane 1:1). White crystals, m.p. 165-166° C.; 1H NMR (CDCl3) □ 8.45-8.42 (m, 1H), 7.92-7.87 (m, dd-like, 1H), 7.21-7.12 (AB-system, 4H), 7.03-6.98 (m, d-like, 1H), 3.72-3.45 (br m, 8H), 1.49 (s, 9H); 13C-NMR (CDCl3) □ (ref. CDCl3 77.00 ppm):165.71, 154.56, 153.51, 150.21, 148.34, 145.43 (q, J=4.4 Hz), 136.701 (q, J=3 Hz), 123.65 (q, J=271.5 Hz), 122.86, 122.24, 121.62 (q, J=33 Hz), 11.20, 80.32, 44.38, 43.78, 44.6-42.3 (br), 28.36 ppm; IR (KBr) □ 1722 (C═O), 1691 (C═O) cm−1.

Provenance & Evidence