HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylamine → 4-(Cyclopropyl-pyridin-4-ylmethyl-amino)-piperidine-1-carboxylic Acid 4-(5-trifluoromethylpyridin-2-yloxy)-phenyl Ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylamine | HCID 7912 | — |
| Reactant | 4-(5-Trifluoromethylpyridin-2-yloxy)-phenyl chloroformate | HCID 22047762 | — |
| Reactant | Cyclopropyl-piperidine-4-yl-pyridin-4-ylmethyl-amine | HCID 22047949 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-(Cyclopropyl-pyridin-4-ylmethyl-amino)-piperidine-1-carboxylic Acid 4-(5-trifluoromethylpyridin-2-yloxy)-phenyl Ester | HCID 69519442 | — |
Reaction Steps
The title product was prepared from cyclopropyl-piperidine-4-yl-pyridin-4-ylmethyl-amine and 4-(5-trifluoromethyl-pyridin-2-yloxy)-phenyl chloroformate, 3 equivalent of diisopropylamine was added, solvent: dimethylformamide. The crude reaction mixture was evaporated without addition of acetic acid, preparative HPLC (method C) (19%, yellow oil). HPLC-MS m/z=(M+1), Rt: 2.82 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07279470B2 |
| Source dataset | uspto-grants-2007_10 |
| ORD ID | ord-c8413a7c59394ae4892305f7db9f8a98 |
| Source note | uspto-grants-2007_10 |