5-Chlorothiophene-2-boronic acid → HCID 69519597, compound

HRID 1180031Notes

Reaction equation

HRID 1180031 reaction equation
I[C:2]1[CH:7]=[CH:6][C:5]([O:8][C:9](=[O:18])[N:10]([CH3:17])[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[CH:4][CH:3]=1.[Cl:19][C:20]1[S:24][C:23](B(O)O)=[CH:22][CH:21]=1>>[Cl:19][C:20]1[S:24][C:23]([C:2]2[CH:7]=[CH:6][C:5]([O:8][C:9](=[O:18])[N:10]([CH3:17])[C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)=[CH:4][CH:3]=2)=[CH:22][CH:21]=1

Participants

3

Reactant 2

HCID 27343245-Chlorothiophene-2-boronic acidHCID 69517304Methyl-phenyl-carbamic Acid 4-iodo-phenyl Ester

Product 1

HCID 69519597HCID 69519597, compound

Procedure

The title compound was prepared from methyl-phenyl-carbamic acid 4-iodo-phenyl ester and 5-chloro-2-thiopheneboronic acid. The crude product was purified by flash chromatography (Quad flash 12, EtOAc-heptane 1:9) (53%, pink crystals).

Workup

  1. customThe crude product was purified by flash chromatography (Quad flash 12, EtOAc-heptane 1:9) (53%, pink crystals)

Sources & evidence

ORD record
ord-94235b9378a04ee18cc294fd23f21ebb
Source dataset
uspto-grants-2007_10
Patent number
US07279470B2

Reaction notes

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