HCID 69517113, compound → HCID 69519907, compound

HRID 1180037Notes

Reaction equation

HRID 1180037 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([S:10]([NH:13][CH2:14][CH2:15][C:16]2[CH:21]=[CH:20][C:19]([O:22][C:23](=[O:32])[N:24]([CH3:31])[C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)=[CH:18][CH:17]=2)(=[O:12])=[O:11])=[CH:6][CH:5]=1)([O-])=O>[Pd].C(O)C>[NH2:1][C:4]1[CH:9]=[CH:8][C:7]([S:10]([NH:13][CH2:14][CH2:15][C:16]2[CH:21]=[CH:20][C:19]([O:22][C:23](=[O:32])[N:24]([CH3:31])[C:25]3[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=3)=[CH:18][CH:17]=2)(=[O:12])=[O:11])=[CH:6][CH:5]=1

Participants

4

Reactant 1

HCID 69517113HCID 69517113, compound

Product 1

HCID 69519907HCID 69519907, compoundYield 94%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

Methyl-phenyl-carbamic acid 4-[2-(4-nitro-benzenesulfonylamino)-ethyl]-phenyl ester, 5% palladium on carbon, and ethanol were stirred under hydrogen at 1 bar and rt for 16 h. Filtration and removal of ethanol produced the title compound in 94% yield as an oil. HPLC-MS: m/z=426.1 (M+1); Rt=3.61 min.

Workup

  1. filtrationFiltration and removal of ethanol

Sources & evidence

ORD record
ord-a408991353eb40c18cf29c1abc9d7756
Source dataset
uspto-grants-2007_10
Patent number
US07279470B2

Reaction notes

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