Methyl-phenyl-carbamic Acid 4-hydroxymethyl-phenyl Ester → Methyl-phenyl-carbamic Acid 4-tetrazol-1-ylmethyl-phenyl Ester

HRID 1180064Notes

Reaction equation

HRID 1180064 reaction equation
O[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([O:9][C:10](=[O:19])[N:11]([CH3:18])[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[CH:5][CH:4]=1.[NH:20]1[CH:24]=[N:23][N:22]=[N:21]1>>[N:20]1([CH2:2][C:3]2[CH:8]=[CH:7][C:6]([O:9][C:10](=[O:19])[N:11]([CH3:18])[C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)=[CH:5][CH:4]=2)[CH:24]=[N:23][N:22]=[N:21]1

Participants

3

Reactant 2

HCID 69518671Methyl-phenyl-carbamic Acid 4-hydroxymethyl-phenyl EsterHCID 178418441HCID 178418441, compound

Product 1

HCID 69520746Methyl-phenyl-carbamic Acid 4-tetrazol-1-ylmethyl-phenyl EsterYield 6%

Procedure

The title compound was prepared in 6% yield as an oil using methyl-phenyl-carbamic acid 4-hydroxymethyl-phenyl ester and tetrazole. 1H NMR (400 MHz; CDCl3): δ 3.42 (br s, 3H), 5.57 (s, 2H), 7.17 (br s, 2H), 7.26-7.42 (m, 7H), 8.52 (s, 1H); HPLC-MS: m/z=332.0 (M+23); Rt=3.24 min.

Sources & evidence

ORD record
ord-0643f5459e184ed580eb8a0e2c14a31f
Source dataset
uspto-grants-2007_10
Patent number
US07279470B2

Reaction notes

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