HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-(3-Amino-phenyl)-pipendine-1-carboxylic acid 4-(5-trifluoromethyl-pyridin2-yloxy)-phenyl Ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 4-(5-Trifluoromethylpyridin-2-yloxy)-phenyl chloroformate | HCID 22047762 | — |
| Reactant | 4-(3-Aminophenyl)piperidine | HCID 22047909 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 4-(3-Amino-phenyl)-pipendine-1-carboxylic acid 4-(5-trifluoromethyl-pyridin2-yloxy)-phenyl Ester | HCID 69519611 | — |
Reaction Steps
The title product was prepared from 4-(3-aminophenyl)piperidine (released form the correspondent hydrochloride by a standard procedure) and 4-(5-trifluoromethyl-pyridin-2-yloxy)-phenyl chloroformate, preparative HPLC (method C) (reaction performed in a mixture of dichloromethane and dimethylformamide, 5:3). 1.7 M HCl in ethyl acetate was added to the pooled fractions containing the title product, and the fractions was evaporated to dryness (7%, light yellow solid). HPLC-MS m/z=(M+1) 458.0, Rt: 3.09 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07279470B2 |
| Source dataset | uspto-grants-2007_10 |
| ORD ID | ord-b739780c364242b9bee6a85a29a98819 |
| Source note | uspto-grants-2007_10 |