Ethyl 3-(3-ethoxy-3-oxopropanamido)-3-methylbutanoate → 3-Piperidinecarboxylic acid, 6,6-dimethyl-2,4-dioxo-, ethyl ester
Reaction equation
[CH2:1]([O:3][C:4](=[O:18])[CH2:5][C:6]([NH:8][C:9]([CH3:17])([CH3:16])[CH2:10][C:11]([O:13]CC)=O)=[O:7])[CH3:2]>C1(C)C=CC=CC=1>[CH3:17][C:9]1([CH3:16])[NH:8][C:6](=[O:7])[CH:5]([C:4]([O:3][CH2:1][CH3:2])=[O:18])[C:11](=[O:13])[CH2:10]1Participants
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 80 °C
Procedure
To a solution of sodium ethoxide, obtained from sodium metal (0.122 g, 5.55 mmol) in anhydrous ethanol (7 mL), a solution of ethyl 3-[(3-ethoxy-3-oxopropanoyl)amino]-3-methylbutanoate (1.2 g, 4.62 mmol) in dry toluene (7 mL) was added dropwise at room temperature, under stirring. The reaction mixture was heated at 80° C. for 2 hours then it was concentrated to reduced volume and the residue was dissolved in toluene (15 mL). The organic phase was extracted with water (40 mL), the aqueous phase was acidified to pH 2-3 with 1 N HCl and extracted with ethyl acetate (4×50 mL). The organic phase was washed with brine, dried over anhydrous sodium sulphate and concentrated to give ethyl 6,6-dimethyl-2,4-dioxopiperidine-3-carboxylate as a yellow solid (0.7 g, Y=71%) which was used for the next step without further purification.
Workup
- concentrationit was concentrated to reduced volume
- dissolutionthe residue was dissolved in toluene (15 mL)
- extractionThe organic phase was extracted with water (40 mL)
- extractionextracted with ethyl acetate (4×50 mL)
- washThe organic phase was washed with brine
- dry with materialdried over anhydrous sodium sulphate
- concentrationconcentrated
Sources & evidence
- ORD record
- ord-b4abaf1d9b5b45a0a08f79efc8129a89
- Source dataset
- uspto-grants-2007_10
- Patent number
- US07279575B2
Reaction notes
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