3-Piperidinecarboxylic acid, 6,6-dimethyl-2,4-dioxo-, ethyl ester → 6,6-Dimethylpiperidine-2,4-dione

Participants

Reaction Steps

Ethyl 6,6-dimethyl-2,4-dioxopiperidine-3-carboxylate (0.69 g, 3.23 mmol) was dissolved in acetonitrile containing 1% of water (15 mL) and the resulting solution was refluxed for 2 hours. After evaporating to dryness, the crude material was suspended in isopropyl ether, kept under vigorous stirring and filtered to give the title compound (387 mg, Y=85%) as a light brown solid.

Provenance & Evidence