HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Ethyl 2-(aminomethyl)-3-methylbutanoate hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 2-Cyano-3-methyl-but-2-enoic acid ethyl ester | HCID 136573 | — |
| Catalyst | Adams' catalyst | HCID 345198 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Ethyl 2-(aminomethyl)-3-methylbutanoate hydrochloride | HCID 71332524 | — |
Reaction Steps
Ethyl 2-cyano-3-methylbut-2-enoate (5.0 g, 32.6 mmol) was dissolved in 320 mL of absolute EtOH. 700 mg of PtO2 and 12 mL of 4M HCl were added. The reaction mixture was hydrogenated at room temperature for 5 hours (30 psi). Filtration on a celite pad and evaporation of the solvent afforded crude title compound (quantitative yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07279575B2 |
| Source dataset | uspto-grants-2007_10 |
| ORD ID | ord-614be658fb454bf7bdb6da79797932af |
| Source note | uspto-grants-2007_10 |