反应详情

温度

40 °C

The mixture of 2-(benzyl-methylcarbamoylmethyl-amino)N-methyl-acetamid (3.09 g, 11.2 mmol) in MeOH (30 mL) was added 10% Pd/C (0.15 g). The mixture was stirred and heated to 40° C. under 40 psi H2 for 10 h, filtered and concentrated in vacuo to yield N-methyl-2-(methylcarbamoylmethyl-amino)-acetamide in quantitative yield (1.76 g). 1HNMR(CDCl3) δ 6.95(brs, 2H), 3.23(s, 4H), 2.79(d, J=4.8 Hz, 6H), 2.25(brs, 1H); MS (ESI) m/e 160(M+H+)

1. filtrationfiltered
2. concentrationconcentrated in vacuo