HCID 21867349, compound → HCID 14518958, compound

HRID 1180104Notes

Reaction equation

HRID 1180104 reaction equation
C([N:8]([CH2:14][C:15](=[O:18])[NH:16][CH3:17])[CH2:9][C:10]([NH:12][CH3:13])=[O:11])C1C=CC=CC=1>CO.[Pd]>[CH3:17][NH:16][C:15](=[O:18])[CH2:14][NH:8][CH2:9][C:10](=[O:11])[NH:12][CH3:13]

Participants

4

Reactant 1

HCID 21867349HCID 21867349, compound

Product 1

HCID 14518958HCID 14518958, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Conditions

Temperature
40 °C

Procedure

The mixture of 2-(benzyl-methylcarbamoylmethyl-amino)N-methyl-acetamid (3.09 g, 11.2 mmol) in MeOH (30 mL) was added 10% Pd/C (0.15 g). The mixture was stirred and heated to 40° C. under 40 psi H2 for 10 h, filtered and concentrated in vacuo to yield N-methyl-2-(methylcarbamoylmethyl-amino)-acetamide in quantitative yield (1.76 g). 1HNMR(CDCl3) δ 6.95(brs, 2H), 3.23(s, 4H), 2.79(d, J=4.8 Hz, 6H), 2.25(brs, 1H); MS (ESI) m/e 160(M+H+)

Workup

  1. filtrationfiltered
  2. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-f9b9c85b6c9c4e33af164179c2f64ed6
Source dataset
uspto-grants-2007_10
Patent number
US07279576B2

Reaction notes

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