HCID 58978218, compound → HCID 58978285, compound

Participants

Reaction Steps

To a solution of Example I (0.73 g, 1.84 mmol) in MeOH (30 mL) was added 10% Pd/C (200 mg). The reaction mixture was then stirred at ambient temperature under 1 atmosphere of H2 for 45 min. The reaction mixture was filtered, the solid washed with EtOH, and the combined organics concentrated in vacuo to yield 4-(bis((methylcarbamoyl)methyl)carbamoyl)benzoic acid (0.52 g, 92% yield). 1H NMR (CDCl3) δ9.16 (s, 1H), 8.05 (d, J=8.4 Hz, 2H), 7.49 (d, J=8.4 Hz, 2H), 4.04 (d, J=6 Hz, 4H), 2.94 (m, 6H); MS (ESI) m/e: 308 (M++1).

Provenance & Evidence