Diisopropyl Ether → HCID 9865778, compound

Participants

Reaction Steps

(2S,4S)-4-Fluoro-1-{[(2-hydroxy-1,1-dimethylethyl)amino]acetyl}pyrrolidine-2-carbonitrile (222 g) was suspended in methanol (3330 mL). While stirring this suspension at room temperature, a methanol solution of benzenesulfonic acid monohydrate (169 g) was gradually added dropwise. After the reaction mixture was stirred at room temperature for 15 minutes, isopropyl ether (3670 mL) was added and stirred at room temperature for 2.5 hours. The precipitated crystal was collected by filtration to give the titled compound (345 g, white powder).

Provenance & Evidence