反应详情

3-Bromo-7-chloro-8-fluoroimidazo[1,2-α]pyridine (45 mg, 0.18 mmol) was coupled with 4,2′-difluoro-5′-(5,5-dimethyl-[1,3,2]dioxaborinan-2-yl)biphenyl-2-carbonitrile (49 mg, 0.19 mmol), as described in Example 1, to afford 5′-(7-chloro-8-fluoroimidazo[1,2-α]pyridin-3-yl)-4,2′-difluorobiphenyl-2-carbonitrile as a white amorphous solid (49 mg, 71%): δH (360 MHz, CDCl3) 6.86 (1H, dd, J 7 and 7), 7.35-7.44 (2H, m), 7.58-7.64 (4H, m), 7.71 (1H, s), 8.20 (1H, d, J 7); m/z (ES+) 384 (100%, [MH]+).