Pyridine,4-(5-bromo-2-fluorophenyl)-3,5-difluoro- → 2-{3-[3-(3,5-Difluoropyridin-4-yl)-4-fluorophenyl]-8-fluoroimidazo[1,2-alpha]pyridin-7-yl}propan-2-ol

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Reaction Steps

2-(8-Fluoroimidazo[1,2-α]pyridin-7-yl)propan-2-ol was coupled to 4-(5-bromo-2-fluorophenyl)-3,5-difluoropyridine as described in Example 6 to give 2-{3-[3-(3,5-difluoropyridin-4-yl)-4-fluorophenyl]-8-fluoroimidazo[1,2-α]pyridin-7-yl}propan-2-ol as an off-white solid (80 mg, 40%): δH (360 MHz, d6-DMSO) 1.57 (6H, s), 7.22 (1H, t, J 7), 7.66 (1H, t, J 9), 7.83 (1H, s), 7.94 (2H, dd, J 6 and 2), 8.37 (1H, d, J 7), 8.75 (2H, s); m/z (ES+) 402 [MH+].

Provenance & Evidence