5'-Bromo-3-chloro-2'-fluorobiphenyl-4-carbonitrile → 3-Chloro-2'-fluoro-5'-[8-fluoro-7-(1-hydroxy-1-methylethyl)imidazo[1,2-alpha]pyridin-3-yl]biphenyl-4-carbonitrile

Participants

Reaction Steps

2-(8-Fluoroimidazo[1,2-α]pyridin-7-yl)propan-2-ol and 5′-bromo-3-chloro-2′-fluorobiphenyl-4-carbonitrile were coupled in the same way as in Example 6 to give 3-chloro-2′-fluoro-5′-[8-fluoro-7-(1-hydroxy-1-methylethyl)imidazo[1,2-α]pyridin-3-yl]biphenyl-4-carbonitrile as an off-white solid (20 mg, 7%): δH (400 MHz, d6-DMSO) 1.59 (6H, s), 7.33 (1H, t, J 7), 7.63 (1H, dd, J 11 and 9), 7.80-7.89 (2H, m), 7.96 (1H, dd, J 7 and 2), 8.03 (1H, s), 8.11-8.14 (2H, m), 8.53 (1H, d, J 7); m/z (ES+) 424 [MH+].

Provenance & Evidence