HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(5-Bromo-2-fluorophenyl)pyrrolidin-2-one → 1-{2-Fluoro-5-[8-fluoro-7-(1-hydroxy-1-methylethyl)imidazo[1,2-alpha]pyridin-3-yl]phenyl}pyrrolidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(5-Bromo-2-fluorophenyl)pyrrolidin-2-one | HCID 17964833 | — |
| Reactant | 2-(8-Fluoroimidazo[1,2-a]pyridin-7-yl)propan-2-ol | HCID 44408729 | — |
| Product | 1-{2-Fluoro-5-[8-fluoro-7-(1-hydroxy-1-methylethyl)imidazo[1,2-alpha]pyridin-3-yl]phenyl}pyrrolidin-2-one | HCID 10406898 | 31% |
Reaction Steps
2-(8-Fluoroimidazo[1,2-α]pyridin-7-yl)propan-2-ol was coupled to 1-(5-bromo-2-fluorophenyl)pyrrolidin-2-one as described in Example 6 to give 1-{2-fluoro-5-[8-fluoro-7-(1-hydroxy-1-methylethyl)imidazo[1,2-α]pyridin-3-yl]phenyl}pyrrolidin-2-one as a pale yellow solid (114 mg, 31%): m/z (ES+) 372 [MH+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07279580B2 |
| Source dataset | uspto-grants-2007_10 |
| ORD ID | ord-294d6a9afff24ea980afe73cece2538b |
| Source note | uspto-grants-2007_10 |