HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(5-Bromo-2-fluorophenyl)-1h-imidazole → 2-{8-Fluoro-3-[4-fluoro-(3-imidazol-1-yl)phenyl]imidazo[1,2-alpha]pyridin-7-yl}propan-2-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(5-Bromo-2-fluorophenyl)-1h-imidazole | HCID 22329507 | — |
| Reactant | 2-(8-Fluoroimidazo[1,2-a]pyridin-7-yl)propan-2-ol | HCID 44408729 | — |
| Product | 2-{8-Fluoro-3-[4-fluoro-(3-imidazol-1-yl)phenyl]imidazo[1,2-alpha]pyridin-7-yl}propan-2-ol | HCID 10247542 | 24% |
Reaction Steps
2-(8-Fluoroimidazo[1,2-α]pyridin-7-yl)propan-2-ol was coupled to 1-(5-bromo-2-fluorophenyl)-1H-imidazole as described in Example 6 to give 2-{8-fluoro-3-[4-fluoro-(3-imidazol-1-yl)phenyl]imidazo[1,2-α]pyridin-7-yl}propan-2-ol as a pale yellow solid (83 mg, 24%): m/z (ES+) 355 [MH+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07279580B2 |
| Source dataset | uspto-grants-2007_10 |
| ORD ID | ord-634ae01970854101b23c2da0ec034182 |
| Source note | uspto-grants-2007_10 |