3'-Bromo-4,5'-difluorobiphenyl-2-carbonitrile → 4,3'-Difluoro-5'-[8-fluoro-7-(1-hydroxy-1-methylethyl)imidazo[1,2-alpha]pyridin-3-yl]-biphenyl-2-carbonitrile

Participants

Reaction Steps

2-(8-Fluoroimidazo[1,2-α]pyridin-7-yl)propan-2-ol (58 mg, 0.3 mmol) and 3′-bromo-4,5′-difluorobiphenyl-2-carbonitrile (106 mg, 0.36 mmol) were coupled following the procedure in Example 6 to afford 4,3′-difluoro-5′-[8-fluoro-7-(1-hydroxy-1-methylethyl)imidazo[1,2-α]pyridin-3-yl]-biphenyl-2-carbonitrile (25 mg, 20%) as a white solid: δH (500 Ndz, CDCl3) 1.74 (6H, s), 2.07 (1H, s), 7.22-7.26 (2H, m), 7.35 (1H, d, J 9), 7.39-7.45 (1H, m), 7.51-7.57 (3H, m), 7.76 (1H, s), 8.35 (1H, d, J 7); m/z (ES+) 408 (100%, [MH]+).

Provenance & Evidence