(2-Ethoxyphenyl)boronic acid → HCID 10092860, compound

HRID 1180280Notes

Reaction equation

HRID 1180280 reaction equation
Cl[C:2]1[CH:3]=[C:4]([C:9]2[N:13]3[CH:14]=[CH:15][C:16]([C:19]([OH:22])([CH3:21])[CH3:20])=[C:17]([F:18])[C:12]3=[N:11][CH:10]=2)[CH:5]=[CH:6][C:7]=1[F:8].[CH2:23]([O:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=1B(O)O)[CH3:24]>>[CH2:23]([O:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=1[C:2]1[CH:3]=[C:4]([C:9]2[N:13]3[CH:14]=[CH:15][C:16]([C:19]([OH:22])([CH3:21])[CH3:20])=[C:17]([F:18])[C:12]3=[N:11][CH:10]=2)[CH:5]=[CH:6][C:7]=1[F:8])[CH3:24]

Participants

3

Reactant 2

HCID 2734902(2-Ethoxyphenyl)boronic acidHCID 674866802-[3-(3-Chloro-4-fluorophenyl)-8-fluoroimidazo[1,2-alpha]pyridin-7-yl]propan-2-ol

Product 1

HCID 10092860HCID 10092860, compoundYield 5%

Procedure

2-[3-(3-Chloro-4-fluorophenyl)-8-fluoroimidazo[1,2-α]pyridin-7-yl]-propan-2-ol and 2-ethoxybenzeneboronic acid were coupled in the same way as in Example 30 to give 2-[3-(2′-ethoxy-2-fluorobiphenyl-5-yl)-8-fluoroimidazo[1,2-α]pyridin-7-yl]propan-2-ol as an off-white solid (6 mg, 5%): m/z (ES+) 409 [MH+].

Sources & evidence

ORD record
ord-8444ebe86e284c3d94ade794a60c6e07
Source dataset
uspto-grants-2007_10
Patent number
US07279580B2

Reaction notes

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